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PDBsum entry 4jia
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Transferase/transferase inhibitor
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PDB id
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4jia
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References listed in PDB file
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Key reference
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Title
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2-Amino-[1,2,4]triazolo[1,5-A]pyridines as jak2 inhibitors.
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Authors
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M.Siu,
R.Pastor,
W.Liu,
K.Barrett,
M.Berry,
W.S.Blair,
C.Chang,
J.Z.Chen,
C.Eigenbrot,
N.Ghilardi,
P.Gibbons,
H.He,
C.A.Hurley,
J.R.Kenny,
S.Cyrus khojasteh,
H.Le,
L.Lee,
J.P.Lyssikatos,
S.Magnuson,
R.Pulk,
V.Tsui,
M.Ultsch,
Y.Xiao,
B.Y.Zhu,
D.Sampath.
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Ref.
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Bioorg Med Chem Lett, 2013,
23,
5014-5021.
[DOI no: ]
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PubMed id
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Abstract
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The advancement of a series of ligand efficient
2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from
high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in
a mouse xenograft model is disclosed.
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