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UniProt functional annotation for P68183 | ||
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| UniProt code: P68183. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217}. |
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| Subunit: | |
The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO:0000269|PubMed:10809785, ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2233678}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2233678}. |
| Miscellaneous: | |
When MalF EAA loop mutations are made concomitantly with MalG EAA loop mutations, a complete loss of transport and complex formation is observed. This suggests that the MalF-MalG interaction may be important for the proper assembly and also for the correct function of the transporter. |
| Similarity: | |
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.