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PDBsum entry 4ja7
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PDB id:
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Hydrolase
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Title:
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Rat pp5 co-crystallized with p5sa-2
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Structure:
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Serine/threonine-protein phosphatase 5. Chain: a. Synonym: pp5, protein phosphatase t, ppt. Engineered: yes
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Source:
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Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: ppp5c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.00Å
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R-factor:
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0.216
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R-free:
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0.262
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Authors:
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V.Haslbeck,M.Helmuth,F.Alte,G.Popowicz,W.Schmidt,M.Weiwad,G.Fischer, G.Gemmecker,M.Sattler,F.Striggow,M.Groll,K.Richter
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Key ref:
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V.Haslbeck
et al.
(2015).
Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci Rep,
35,
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PubMed id:
DOI:
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Date:
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18-Feb-13
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Release date:
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19-Feb-14
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PROCHECK
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Headers
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References
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P53042
(PPP5_RAT) -
Serine/threonine-protein phosphatase 5 from Rattus norvegicus
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Seq:
Struc:
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499 a.a.
466 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.1.3.16
- protein-serine/threonine phosphatase.
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Reaction:
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1.
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O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
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2.
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O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate
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O-phospho-L-seryl-[protein]
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+
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H2O
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=
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L-seryl-[protein]
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+
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phosphate
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O-phospho-L-threonyl-[protein]
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+
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H2O
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=
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L-threonyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Biosci Rep
35:
(2015)
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PubMed id:
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Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
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V.Haslbeck,
A.Drazic,
J.M.Eckl,
F.Alte,
M.Helmuth,
G.Popowicz,
W.Schmidt,
F.Braun,
M.Weiwad,
G.Fischer,
G.Gemmecker,
M.Sattler,
F.Striggow,
M.Groll,
K.Richter.
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ABSTRACT
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