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UniProt functional annotation for U3KRG1 | ||
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| UniProt code: U3KRG1. |
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| Organism: | |
Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops. |
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| Function: | |
Potent fibrinogenolytic protease which cleaves mainly the Aalpha (FGA) and Bbeta (FGB) chains of fibrinogen and slightly the gamma chain (FGG) (PubMed:8193588, PubMed:7488093). Shows preference for substrates having a moderate-size and hydrophobic residue at the P1' position. Preferentially cleaves Ala-|-Leu and Tyr-|-Leu bonds (PubMed:23732127). Is more susceptible to tripeptide inhibitors than TM-3 (AC O57413) (PubMed:9703966). {ECO:0000269|PubMed:23732127, ECO:0000269|PubMed:7488093, ECO:0000269|PubMed:8193588, ECO:0000269|PubMed:9703966}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305|PubMed:23732127}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:23732127}; |
| Activity regulation: | |
Inhibited by EDTA and 1,10-phenanthroline (PubMed:8193588). Is also inhibited by endogenous tripeptide inhibitors pyroGlu-Asn-Trp, pyroGlu-Gln-Trp, and pyroGlu-Lys-Trp (PubMed:9703966). {ECO:0000269|PubMed:8193588, ECO:0000269|PubMed:9703966}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:7488093, ECO:0000269|PubMed:8193588}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:7488093, ECO:0000269|PubMed:8193588}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:7488093, ECO:0000305|PubMed:8193588}. |
| Ptm: | |
The N-terminus is blocked. {ECO:0000269|PubMed:7488093}. |
| Ptm: | |
Not glycosylated. {ECO:0000269|PubMed:23732127}. |
| Similarity: | |
Belongs to the venom metalloproteinase (M12B) family. P-I subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.