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UniProt functional annotation for O43818 | ||
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| UniProt code: O43818. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). {ECO:0000269|PubMed:26867678}. |
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| Subunit: | |
Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA) (PubMed:10982864, PubMed:12381732). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC) (PubMed:10982864, PubMed:12381732). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif (PubMed:10982864, PubMed:12381732). The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif (PubMed:10982864, PubMed:12381732). {ECO:0000269|PubMed:10982864, ECO:0000269|PubMed:12381732}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:9418896}. |
| Domain: | |
The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding. {ECO:0000269|PubMed:10982864}. |
| Ptm: | |
Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing (PubMed:26867678). Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre- rRNA processing (PubMed:26867678). {ECO:0000269|PubMed:26867678}. |
| Similarity: | |
Belongs to the WD repeat RRP9 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.