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PDBsum entry 4ihp
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Transferase/transferase inhibitor
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PDB id
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4ihp
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Crystal structure of tgcdpk1 with inhibitor bound
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Structure:
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Calmodulin-domain protein kinase 1. Chain: a. Synonym: calmodulin-domain protein kinase, putative. Engineered: yes
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Source:
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Toxoplasma gondii. Organism_taxid: 5811. Gene: cdpk1, tggt1_059880, tgveg_042030. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.27Å
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R-factor:
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0.195
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R-free:
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0.251
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Authors:
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M.El Bakkouri,W.Tempel,I.E.Crandall,T.Massad,P.Loppnau,S.Graslund, C.Bountra,C.H.Arrowsmith,A.M.Edwards,C.K.Kain,K.M.Shokat,L.D.Sibley, R.Hui,Structural Genomics Consortium (Sgc)
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Key ref:
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M.El bakkouri
et al.
Crystal structure of tgcdpk1 with inhibitor bound.
To be published,
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Date:
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19-Dec-12
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Release date:
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15-Jan-14
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PROCHECK
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Headers
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References
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Q9BJF5
(Q9BJF5_TOXGO) -
Calmodulin-domain protein kinase 1 from Toxoplasma gondii
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Seq:
Struc:
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507 a.a.
454 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.17
- calcium/calmodulin-dependent protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Cofactor:
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Ca(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
