UniProt functional annotation for Q13163

UniProt code: Q13163.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.
 
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Subunit: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ. {ECO:0000250, ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:7759517, ECO:0000269|Ref.12, ECO:0000269|Ref.13}.
Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Domain: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity). {ECO:0000250}.
Ptm: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. {ECO:0000250}.
Ptm: Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. {ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:7759517}.
Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.