PDBsum entry 4i9x

Apoptosis

PDB id: 4i9x

Contents

Protein chains

187 a.a.

188 a.a.

105 a.a.

Ligands

NAG-NAG ×2

NAG

Metals

_CA ×4

_NA

Waters ×239

PDB id:

4i9x

Name:

Apoptosis

Title:

Crystal structure of human cytomegalovirus glycoprotein ul141 targeting the death receptor trail-r2

Structure:

Protein ul141. Chain: a, b. Fragment: ul141, unp residues 32-246. Engineered: yes. Tumor necrosis factor receptor superfamily member 10b. Chain: c, d. Fragment: trail-r2, unp residues 58-184. Synonym: death receptor 5, tnf-related apoptosis-inducing ligand receptor 2, trail receptor 2, trail-r2.

Source:

Human herpesvirus 5. Hhv-5. Organism_taxid: 295027. Strain: merlin. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

2.10Å R-factor: 0.224 R-free: 0.274

Authors:

I.Nemcovicova,D.M.Zajonc

Key ref:

I.Nemčovičová et al. (2013). Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions. Plos Pathog, 9, e1003224. PubMed id: 23555243 DOI: 10.1371/journal.ppat.1003224

Date:

05-Dec-12 Release date: 03-Apr-13

Protein chain

Q6RJQ3  (UL141_HCMVM) -  Protein UL141 from Human cytomegalovirus (strain Merlin)

Seq: 338 a.a.

Struc: 187 a.a.

Protein chain

Q6RJQ3  (UL141_HCMVM) -  Protein UL141 from Human cytomegalovirus (strain Merlin)

Seq: 338 a.a.

Struc: 188 a.a.

Protein chains

O14763  (TR10B_HUMAN) -  Tumor necrosis factor receptor superfamily member 10B from Homo sapiens

Seq: 440 a.a.

Struc: 105 a.a.

DOI no: 10.1371/journal.ppat.1003224

Plos Pathog 9:e1003224 (2013)

PubMed id: 23555243

Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.

I.Nemčovičová, C.A.Benedict, D.M.Zajonc.

ABSTRACT

No abstract given.