PDBsum entry 4i18

Cytokine, signaling protein

PDB id: 4i18

Contents

Protein chains

216 a.a.

227 a.a.

205 a.a.

188 a.a.

Ligands

GOL ×4

ACT

Metals

_CA ×2

PDB id:

4i18

Name:

Cytokine, signaling protein

Title:

Crystal structure of human prolactin receptor complexed with fab fragment

Structure:

Antibody light chain. Chain: l, b. Fragment: fab. Engineered: yes. Antibody heavy chain. Chain: h, a. Fragment: fab. Engineered: yes. Prolactin receptor.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: prlr.

Resolution:

3.24Å R-factor: 0.194 R-free: 0.246

Authors:

E.M.Duguid,S.Mukherjee,J.L.Kouadio

Key ref:

S.S.Rizk et al. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Commun Signal, 13, 1. PubMed id: 25589173 DOI: 10.1186/s12964-014-0080-8

Date:

20-Nov-12 Release date: 20-Nov-13

Protein chains

No UniProt id for this chain

Struc: 216 a.a.

Protein chains

No UniProt id for this chain

Struc: 227 a.a.

Protein chain

P16471  (PRLR_HUMAN) -  Prolactin receptor from Homo sapiens

Seq: 622 a.a.

Struc: 205 a.a.

Protein chain

P16471  (PRLR_HUMAN) -  Prolactin receptor from Homo sapiens

Seq: 622 a.a.

Struc: 188 a.a.

DOI no: 10.1186/s12964-014-0080-8

Cell Commun Signal 13:1 (2015)

PubMed id: 25589173

Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.

S.S.Rizk, J.L.Kouadio, A.Szymborska, E.M.Duguid, S.Mukherjee, J.Zheng, C.V.Clevenger, A.A.Kossiakoff.

ABSTRACT

No abstract given.