PDBsum entry 4h1o

Hydrolase

PDB id: 4h1o

Contents

Protein chain

496 a.a.

Ligands

EDO ×5

Waters ×134

PDB id:

4h1o

Name:

Hydrolase

Title:

Crystal structure of the tyrosine phosphatase shp-2 with d61g mutation

Structure:

Tyrosine-protein phosphatase non-receptor type 11. Chain: a. Fragment: n-sh2, c-sh2 and phosphatase domain. Synonym: protein-tyrosine phosphatase 1d, ptp-1d, protein-tyrosine phosphatase 2c, ptp-2c, sh-ptp2, shp-2, shp2, sh-ptp3. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn11, ptp2c, shptp2. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å R-factor: 0.211 R-free: 0.233

Authors:

W.Qiu,A.Lin,A.Hutchinson,V.Romanov,M.Ruzanov,C.Thompson,K.Lam, G.Kisselman,K.Battaile,N.Y.Chirgadze

Key ref:

W.Qiu et al. Crystal structure of the tyrosine phosphatase shp-2 w d61g mutation. To be published, .

Date:

11-Sep-12 Release date: 11-Sep-13

Protein chain

Q06124  (PTN11_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 11 from Homo sapiens

Seq: 593 a.a.

Struc: 496 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site