PDBsum entry 4gs0

Hydrolase/transferase

PDB id: 4gs0

Contents

Protein chains

279 a.a.

258 a.a.

Ligands

UNK-UNK-FTY-UNK

Waters ×287

PDB id:

4gs0

Name:

Hydrolase/transferase

Title:

Crystal structure of shp1 catalytic domain with jak1 activation loop peptide

Structure:

Tyrosine-protein phosphatase non-receptor type 6. Chain: a, b. Fragment: phosphatase domain (unp residues 242-528). Synonym: hematopoietic cell protein-tyrosine phosphatase, protein- tyrosine phosphatase 1c, ptp-1c, protein-tyrosine phosphatase shp-1, sh-ptp1. Engineered: yes. Tyrosine-protein kinase jak1. Chain: c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hcp, ptp1c, ptpn6, shp-1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.80Å R-factor: 0.163 R-free: 0.195

Authors:

N.L.Alicea-Velazquez,J.Jakoncic,T.J.Boggon

Key ref:

N.L.Alicea-Velázquez et al. (2013). Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J Struct Biol, 181, 243-251. PubMed id: 23296072 DOI: 10.1016/j.jsb.2012.12.009

Date:

27-Aug-12 Release date: 19-Dec-12

Protein chain

P29350  (PTN6_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 6 from Homo sapiens

Seq: 595 a.a.

Struc: 279 a.a.

Protein chain

P29350  (PTN6_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 6 from Homo sapiens

Seq: 595 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

DOI no: 10.1016/j.jsb.2012.12.009

J Struct Biol 181:243-251 (2013)

PubMed id: 23296072

Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.

N.L.Alicea-Velázquez, J.Jakoncic, T.J.Boggon.

ABSTRACT

No abstract given.