PDBsum entry 4grz

Hydrolase

PDB id: 4grz

Contents

Protein chain

282 a.a.

Ligands

PO4

Waters ×391

PDB id:

4grz

Name:

Hydrolase

Title:

Crystal structure of shp1 catalytic domain with po4

Structure:

Tyrosine-protein phosphatase non-receptor type 6. Chain: a. Fragment: phosphatase domain unp residues 242-528. Synonym: hematopoietic cell protein-tyrosine phosphatase, protein- tyrosine phosphatase 1c, ptp-1c, protein-tyrosine phosphatase shp-1, sh-ptp1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hcp, ptp1c, ptpn6, shp-1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.37Å R-factor: 0.170 R-free: 0.189

Authors:

N.L.Alicea-Velazquez,J.Jakoncic,T.J.Boggon

Key ref:

N.L.Alicea-Velázquez et al. (2013). Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J Struct Biol, 181, 243-251. PubMed id: 23296072 DOI: 10.1016/j.jsb.2012.12.009

Date:

27-Aug-12 Release date: 19-Dec-12

Protein chain

P29350  (PTN6_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 6 from Homo sapiens

Seq: 595 a.a.

Struc: 282 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (Bound ligand (Het Group name = PO4) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

DOI no: 10.1016/j.jsb.2012.12.009

J Struct Biol 181:243-251 (2013)

PubMed id: 23296072

Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.

N.L.Alicea-Velázquez, J.Jakoncic, T.J.Boggon.

ABSTRACT

No abstract given.