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PDBsum entry 4gl9
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protein ligands Protein-protein interface(s) links
Transferase/transferase inhibitor PDB id
4gl9

 

 

 

 

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Contents
Protein chains
284 a.a.
124 a.a.
Ligands
VAL-GLU-PTR-SER-
THR-VAL-VAL-HIS ×3
THR-VAL-GLU-PTR-
SER-THR-VAL-VAL-
HIS
IZA ×4
PO4
PDB id:
4gl9
Name: Transferase/transferase inhibitor
Title: Crystal structure of inhibitory protein socs3 in complex with jak2 kinase domain and fragment of gp130 intracellular domain
Structure: Tyrosine-protein kinase. Chain: a, b, c, d. Fragment: kinase domain (unp residues 836-1132). Engineered: yes. Interleukin-6 receptor subunit beta. Chain: i, k, j, l. Fragment: unp residues 750-764. Synonym: il-6rb,interleukin-6 signal transducer,membrane glycoprotein 130,gp130,oncostatin-m receptor subunit alpha.
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: jak2, mcg_9104. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Mouse, mouse. Gene: socs3, cis3, cish3.
Resolution:
3.90Å     R-factor:   0.254     R-free:   0.281
Authors: N.J.Kershaw,J.M.Murphy,A.Laktyushin,N.A.Nicola,J.J.Babon
Key ref: N.J.Kershaw et al. (2013). SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat Struct Biol, 20, 469-476. PubMed id: 23454976 DOI: 10.1038/nsmb.2519
Date:
14-Aug-12     Release date:   06-Mar-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q62120  (JAK2_MOUSE) -  Tyrosine-protein kinase JAK2 from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1132 a.a.
284 a.a.
Protein chains
Pfam   ArchSchema ?
O35718  (SOCS3_MOUSE) -  Suppressor of cytokine signaling 3 from Mus musculus
Seq:
Struc: 		225 a.a.
124 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.2.7.10.2  - non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
DOI no: 10.1038/nsmb.2519 Nat Struct Biol 20:469-476 (2013)
PubMed id: 23454976  
 
 
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
N.J.Kershaw, J.M.Murphy, N.P.Liau, L.N.Varghese, A.Laktyushin, E.L.Whitlock, I.S.Lucet, N.A.Nicola, J.J.Babon.
 
  ABSTRACT  
 
No abstract given.

 

 

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