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UniProt functional annotation for P06734 | ||
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| UniProt code: P06734. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). |
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| Subunit: | |
Homotrimer. {ECO:0000269|PubMed:16172256, ECO:0000269|PubMed:16765898}. |
| Subcellular location: | |
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23. |
| Ptm: | |
N- and O-glycosylated. |
| Ptm: | |
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| Miscellaneous: | |
There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes. |
| Sequence caution: | |
Sequence=AAA52433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.