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PDBsum entry 4gfv
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Hydrolase/peptide
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PDB id
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4gfv
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PDB id:
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| Name: |
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Hydrolase/peptide
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Title:
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Ptpn18 in complex with her2-py1196 phosphor-peptides
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Structure:
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Tyrosine-protein phosphatase non-receptor type 18. Chain: a, b. Fragment: unp residues 6-300. Synonym: brain-derived phosphatase. Engineered: yes. Mutation: yes. Her2-py1196 phosphor-peptide. Chain: e, f. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn18, bdp1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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2.10Å
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R-factor:
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0.248
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R-free:
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0.293
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Authors:
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H.M.Wang,F.Yang,Y.J.Du,D.X.Yang,Y.Zhang,X.Yu,J.P.Sun
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Key ref:
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H.M.Wang
et al.
Ptpn18-Her2 peptides.
To be published,
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Date:
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04-Aug-12
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Release date:
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23-Oct-13
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PROCHECK
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Headers
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References
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Q99952
(PTN18_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 18 from Homo sapiens
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Seq:
Struc:
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460 a.a.
286 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
