PDBsum entry 4gfm

Transferase/transferase inhibitor

PDB id: 4gfm

Contents

Protein chain

291 a.a.

Ligands

0X2

Waters ×141

PDB id:

4gfm

Name:

Transferase/transferase inhibitor

Title:

Jak2 kinase (jh1 domain) with 2,6-dichloro-n-(2-oxo-2,5- dihydropyridin-4-yl)benzamide

Structure:

Tyrosine-protein kinase jak2. Chain: a. Fragment: jh1 domain, unp residues 833-1132. Synonym: janus kinase 2, jak-2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.30Å R-factor: 0.171 R-free: 0.242

Authors:

C.Eigenbrot,M.Ultsch

Key ref:

J.Liang et al. (2013). Lead identification of novel and selective TYK2 inhibitors. Eur J Med Chem, 67, 175-187. PubMed id: 23867602 DOI: 10.1016/j.ejmech.2013.03.070

Date:

03-Aug-12 Release date: 19-Jun-13

Protein chain

O60674  (JAK2_HUMAN) -  Tyrosine-protein kinase JAK2 from Homo sapiens

Seq: 1132 a.a.

Struc: 291 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.ejmech.2013.03.070

Eur J Med Chem 67:175-187 (2013)

PubMed id: 23867602

Lead identification of novel and selective TYK2 inhibitors.

J.Liang, V.Tsui, A.Van Abbema, L.Bao, K.Barrett, M.Beresini, L.Berezhkovskiy, W.S.Blair, C.Chang, J.Driscoll, C.Eigenbrot, N.Ghilardi, P.Gibbons, J.Halladay, A.Johnson, P.B.Kohli, Y.Lai, M.Liimatta, P.Mantik, K.Menghrajani, J.Murray, A.Sambrone, Y.Xiao, S.Shia, Y.Shin, J.Smith, S.Sohn, M.Stanley, M.Ultsch, B.Zhang, L.C.Wu, S.Magnuson.

ABSTRACT

No abstract given.