PDBsum entry 4gfg

Transferase/transferase inhibitor

PDB id: 4gfg

Contents

Protein chain

277 a.a.

Ligands

0XF

Waters ×101

PDB id:

4gfg

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of spleen tyrosine kinase complexed with r9021

Structure:

Tyrosine-protein kinase syk. Chain: a. Fragment: kinase domain. Synonym: spleen tyrosine kinase, p72-syk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Resolution:

2.35Å R-factor: 0.221 R-free: 0.246

Authors:

C.Lukacs,M.Slade

Key ref:

J.Hsu et al. A specific syk inhibitor blocks b cell receptor, Fc receptor, And toll-Like receptor 9 pathways for the treatment of inflammatory diseases.. To be published, .

Date:

03-Aug-12 Release date: 14-Aug-13

Protein chain

P43405  (KSYK_HUMAN) -  Tyrosine-protein kinase SYK from Homo sapiens

Seq: 635 a.a.

Struc: 277 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site