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UniProt functional annotation for Q9XWG3 | ||
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| UniProt code: Q9XWG3. |
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| Organism: | |
Caenorhabditis elegans. |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. |
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| Function: | |
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. {ECO:0000250|UniProtKB:Q9JJX7}. |
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| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:23104058}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q9JJX7}; Note=Binds 1 magnesium or manganese ion per subunit. {ECO:0000269|PubMed:23104058}; |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:O95551}. Nucleus, PML body {ECO:0000250|UniProtKB:O95551}. |
| Similarity: | |
Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.