UniProt functional annotation for Q9PTN2



	UniProt functional annotation for Q9PTN2

UniProt code: Q9PTN2.

Organism: Danio rerio (Zebrafish) (Brachydanio rerio).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio.

Function: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. {ECO:0000250|UniProtKB:P11473}.

Subunit: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes (PubMed:17218092, PubMed:17346665). {ECO:0000250|UniProtKB:P11473, ECO:0000269|PubMed:17218092, ECO:0000269|PubMed:17346665}.

Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:P11473}. Note=Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3. {ECO:0000250|UniProtKB:P11473}.

Tissue specificity: Detected in embryo 24 to 48 hours after fertilization and in gastrula. {ECO:0000269|PubMed:17997606}.

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Domain: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. {ECO:0000250|UniProtKB:P11473}.

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Danio rerio (Zebrafish) (Brachydanio rerio).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio.



Function:		Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. {ECO:0000250\|UniProtKB:P11473}.


Subunit:		Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes (PubMed:17218092, PubMed:17346665). {ECO:0000250\|UniProtKB:P11473, ECO:0000269\|PubMed:17218092, ECO:0000269\|PubMed:17346665}.
Subcellular location:		Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250\|UniProtKB:P11473}. Note=Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3. {ECO:0000250\|UniProtKB:P11473}.
Tissue specificity:		Detected in embryo 24 to 48 hours after fertilization and in gastrula. {ECO:0000269\|PubMed:17997606}.
Domain:		Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Domain:		The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. {ECO:0000250\|UniProtKB:P11473}.
Similarity:		Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.