PDBsum entry 4fxs

Oxidoreductase

PDB id: 4fxs

Contents

Protein chain

467 a.a.

Ligands

IMP

MOA

Metals

__K

Waters ×87

PDB id:

4fxs

Name:

Oxidoreductase

Title:

Inosine 5'-monophosphate dehydrogenase from vibrio cholerae complexed with imp and mycophenolic acid

Structure:

Inosine-5'-monophosphate dehydrogenase. Chain: a. Engineered: yes

Source:

Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: vc0767, vc_0767. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.24Å R-factor: 0.192 R-free: 0.232

Authors:

J.Osipiuk,N.Maltseva,M.Makowska-Grzyska,R.Jedrzejczak,W.F.Anderson, A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

J.Osipiuk et al. Inosine 5'-Monophosphate dehydrogenase from vibrio ch complexed with imp and mycophenolic acid.. To be published, .

Date:

03-Jul-12 Release date: 25-Jul-12

Protein chain

Q9KTW3  (Q9KTW3_VIBCH) -  Inosine-5'-monophosphate dehydrogenase from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

Seq: 489 a.a.

Struc: 467 a.a.

Enzyme reactions

• Enzyme class: E.C.1.1.1.205 - Imp dehydrogenase.
• Pathway: AMP and GMP Biosynthesis
• Reaction: IMP + NAD⁺ + H2O = XMP + NADH + H⁺

IMP (Bound ligand (Het Group name = IMP) corresponds exactly) + NAD(+) + H2O = XMP + NADH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site