PDBsum entry 4fww

Transferase

PDB id: 4fww

Contents

Protein chain

513 a.a.

Ligands

NAG-NAG-BMA-BMA

SO4 ×2

ACT ×5

GOL ×4

EDO ×4

PEG

Waters ×358

PDB id:

4fww

Name:

Transferase

Title:

Crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase

Structure:

Macrophage-stimulating protein receptor. Chain: a. Fragment: extracellular sema and psi domains (unp residues 42-568). Synonym: msp receptor, cdw136, protein-tyrosine kinase 8, p185-ron, macrophage-stimulating protein receptor alpha chain, macrophage- stimulating protein receptor beta chain. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mst1r, ptk8, ron. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.

Resolution:

1.85Å R-factor: 0.193 R-free: 0.232

Authors:

K.L.Chao,O.Herzberg

Key ref:

K.L.Chao et al. (2012). Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. Plos One, 7, e41912. PubMed id: 22848655

Date:

02-Jul-12 Release date: 08-Aug-12

Protein chain

Q04912  (RON_HUMAN) -  Macrophage-stimulating protein receptor from Homo sapiens

Seq: 1400 a.a.

Struc: 513 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = NAG) matches with 41.38% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Plos One 7:e41912 (2012)

PubMed id: 22848655

Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase.

K.L.Chao, I.W.Tsai, C.Chen, O.Herzberg.

ABSTRACT

No abstract given.