PDBsum entry 4fu8

Hydrolase/hydrolase inhibitor

PDB id: 4fu8

Contents

Protein chain

246 a.a.

Ligands

2UP

ACT ×2

SIN

SO4 ×4

Waters ×241

PDB id:

4fu8

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of the urokinase

Structure:

Urokinase-type plasminogen activator. Chain: a. Synonym: u-plasminogen activator, upa, urokinase-type plasminogen activator long chain a, urokinase-type plasminogen activator short chain a, urokinase-type plasminogen activator chain b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å R-factor: 0.195 R-free: 0.239

Authors:

Y.N.Kang,J.A.Stuckey,V.Nienaber,V.Giranda

Key ref:

Y.N.Kang et al. Crystal structure of the urokinase. To be published, .

Date:

28-Jun-12 Release date: 22-Aug-12

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 246 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.