UniProt functional annotation for P28067

UniProt code: P28067.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
 
Subunit: Heterodimer of an alpha chain (DMA) and a beta chain (DMB). {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:9768757}.
Subcellular location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Polymorphism: The following alleles of DMA are known: DMA*01:01, DMA*01:02, DMA*01:03 (DMA3.2) and DMA*01:04 (DMA3.4). The sequence shown is that of DMA*01:01.
Similarity: Belongs to the MHC class II family. {ECO:0000305}.
Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.