spacer
spacer

PDBsum entry 4fpe

Go to PDB code: 
Top Page protein ligands links
Hydrolase/inhibitor PDB id
4fpe
Jmol
Contents
Protein chain
658 a.a.
Ligands
0H9
DMS ×2
Waters ×458

References listed in PDB file
Key reference
Title Synthesis and structural characterisation of selective non-Carbohydrate-Based inhibitors of bacterial sialidases.
Authors P.Brear, J.Telford, G.L.Taylor, N.J.Westwood.
Ref. Chembiochem, 2012, 13, 2374-2383.
PubMed id 23070966
DOI number 10.1002/CBIC.201200433
Abstract
The major human pathogen Streptococcus pneumoniae plays a key role in several disease states including septicaemia, meningitis and community-acquired pneumonia. Although vaccines against S. pneumoniae are available as prophylactics, there remains a need to identify and characterise novel chemical entities that can treat the diseases caused by this pathogen. S. pneumoniae expresses three sialidases, enzymes that cleave sialic acid from carbohydrate-based surface molecules. Two of these enzymes, NanA and NanB, have been implicated in the pathogenesis of S. pneumoniae and are considered to be validated drug targets. Here we report our studies on the synthesis and structural characterisation of novel NanB-selective inhibitors that are inspired by the β-amino-sulfonic acid family of buffers.
PROCHECK
Go to PROCHECK summary
 Headers