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PDBsum entry 4flp
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Transcription regulator/inhibitor
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PDB id
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4flp
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PDB id:
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| Name: |
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Transcription regulator/inhibitor
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Title:
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Crystal structure of the first bromodomain of human brdt in complex with the inhibitor jq1
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Structure:
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Bromodomain testis-specific protein. Chain: a, b. Fragment: first bromodomain (unp residues 21-137). Synonym: cancer/testis antigen 9, ct9, ring3-like protein. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: brdt. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.23Å
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R-factor:
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0.213
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R-free:
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0.255
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Authors:
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P.Filippakopoulos,S.Picaud,J.Qi,I.Felletar,P.Canning,J.Muniz,F.Von Delft,C.Bountra,C.H.Arrowsmith,A.Edwards,J.Bradner,S.Knapp, Structural Genomics Consortium (Sgc)
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Key ref:
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M.M.Matzuk
et al.
(2012).
Small-molecule inhibition of BRDT for male contraception.
Cell,
150,
673-684.
PubMed id:
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Date:
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15-Jun-12
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Release date:
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11-Jul-12
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PROCHECK
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Headers
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References
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Q58F21
(BRDT_HUMAN) -
Bromodomain testis-specific protein from Homo sapiens
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Seq:
Struc:
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947 a.a.
106 a.a.
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Key: |
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Secondary structure |
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CATH domain |
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Cell
150:673-684
(2012)
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PubMed id:
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Small-molecule inhibition of BRDT for male contraception.
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M.M.Matzuk,
M.R.McKeown,
P.Filippakopoulos,
Q.Li,
L.Ma,
J.E.Agno,
M.E.Lemieux,
S.Picaud,
R.N.Yu,
J.Qi,
S.Knapp,
J.E.Bradner.
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ABSTRACT
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Links
