PDBsum entry 4fgy

Transcription/transferase/antibiotic

PDB id

4fgy

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Contents

			Protein chains

					265 a.a.


					11 a.a.

			Ligands

					0W3

			Waters ×18

PDB id:

4fgy

Links

Name:

Transcription/transferase/antibiotic

Title:

Identification of a unique ppar ligand with an unexpected binding mode and antibetic activity

Structure:

Peroxisome proliferator-activated receptor gamma. Chain: a. Fragment: ligand binding domain, unp residues 235-504. Synonym: ppar-gamma, nuclear receptor subfamily 1 group c member 3. Engineered: yes. Nuclear receptor coactivator 1. Chain: b. Fragment: unp residues 686-696. Synonym: ncoa-1, class e basic helix-loop-helix protein 74, bhlhe74,

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: nr1c3, pparg. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.84Å

R-factor:

0.222

R-free:

0.285

Authors:

R.Wang,Y.Li

Key ref:

W.Zheng et al. (2013). Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia, 56, 401-411. PubMed id: 23178929

Date:

05-Jun-12

Release date:

20-Mar-13

PROCHECK

	Headers

	References

Protein chain

P37231 (PPARG_HUMAN) - Peroxisome proliferator-activated receptor gamma from Homo sapiens

Seq: Struc:					505 a.a. 265 a.a.

Protein chain

Q15788 (NCOA1_HUMAN) - Nuclear receptor coactivator 1 from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:					1441 a.a. 11 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

Chain B: E.C.2.3.1.48 - histone acetyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

L-lysyl-[protein]	+	acetyl-CoA	=	N(6)-acetyl-L-lysyl-[protein]	+	CoA	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Diabetologia 56:401-411 (2013)
PubMed id: 23178929

Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.
W.Zheng, X.Feng, L.Qiu, Z.Pan, R.Wang, S.Lin, D.Hou, L.Jin, Y.Li.

ABSTRACT

No abstract given.