PDBsum entry 4ff8

Transferase/transferase inhibitor

PDB id: 4ff8

Contents

Protein chain

169 a.a.

Ligands

14S

Waters ×3

PDB id:

4ff8

Name:

Transferase/transferase inhibitor

Title:

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)

Structure:

Tyrosine-protein kinase receptor tyro3. Chain: a. Synonym: etk2/tyro3, tk19-2, tyrosine-protein kinase dtk, tyrosine- protein kinase rse. Engineered: yes. Mutation: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyro3, dtk, rse. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.40Å R-factor: 0.279 R-free: 0.324

Authors:

J.F.Ohren,N.A.Powell,J.Kohrt,L.A.Perrin

Key ref:

N.A.Powell et al. (2013). Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett, 23, 1046-1050. PubMed id: 23312472

Date:

31-May-12 Release date: 13-Mar-13

Protein chain

P55144  (TYRO3_MOUSE) -  Tyrosine-protein kinase receptor TYRO3 from Mus musculus

Seq: 880 a.a.

Struc: 169 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Bioorg Med Chem Lett 23:1046-1050 (2013)

PubMed id: 23312472

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

N.A.Powell, J.K.Hoffman, F.L.Ciske, M.D.Kaufman, J.T.Kohrt, J.Quin, D.J.Sheehan, A.Delaney, S.M.Baxi, C.Catana, P.McConnell, J.Ohren, L.A.Perrin, J.J.Edmunds.

ABSTRACT

We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhibit good inhibition activity and excellent kinase selectivity.