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UniProt functional annotation for Q9UXG1 | ||
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| UniProt code: Q9UXG1. |
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| Organism: | |
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus. |
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| Function: | |
Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits. {ECO:0000269|PubMed:11821426}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:17964268, ECO:0000269|PubMed:19073923}; |
| Activity regulation: | |
Inhibited by the cdc6-2 protein. The ATPase activity is not stimulated in the presence of DNA molecules. |
| Subunit: | |
Homohexamers. Forms a complex with SSB. {ECO:0000269|PubMed:18417534, ECO:0000269|PubMed:19073923}. |
| Similarity: | |
Belongs to the MCM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.