PDBsum entry 4fdd

Transport protein

PDB id: 4fdd

Contents

Protein chains

836 a.a.

20 a.a.

Waters ×148

PDB id:

4fdd

Name:

Transport protein

Title:

Crystal structure of kap beta2-py-nls

Structure:

Transportin-1. Chain: a. Synonym: importin beta-2, karyopherin beta-2, m9 region interaction protein, mip. Engineered: yes. RNA-binding protein fus. Chain: b. Synonym: 75 kda DNA-pairing protein, oncogene fus, oncogene tls, pomp75, translocated in liposarcoma protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kpnb2, mip1, tnpo1, transportin-1, trn. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fus, tls.

Resolution:

2.30Å R-factor: 0.287 R-free: 0.245

Authors:

Z.C.Zhang,Y.M.Chook

Key ref:

Z.C.Zhang and Y.M.Chook (2012). Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc Natl Acad Sci U S A, 109, 12017-12021. PubMed id: 22778397

Date:

28-May-12 Release date: 18-Jul-12

Protein chain

Q92973  (TNPO1_HUMAN) -  Transportin-1 from Homo sapiens

Seq: 898 a.a.

Struc: 836 a.a.

Protein chain

P35637  (FUS_HUMAN) -  RNA-binding protein FUS from Homo sapiens

Seq: 526 a.a.

Struc: 20 a.a.

Proc Natl Acad Sci U S A 109:12017-12021 (2012)

PubMed id: 22778397

Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).

Z.C.Zhang, Y.M.Chook.

ABSTRACT

No abstract given.