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PDBsum entry 4fat
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Transport protein, membrane protein
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PDB id
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4fat
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PDB id:
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| Name: |
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Transport protein, membrane protein
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Title:
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Ligand-binding domain of glua2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
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Structure:
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Glutamate receptor 2. Chain: a. Fragment: ligand binding domain. Synonym: glur-2, ampa-selective glutamate receptor 2, glur-b, glur- k2, glutamate receptor ionotropic, ampa 2, glua2. Engineered: yes. Mutation: yes
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Source:
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Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: gria2, glur2. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.40Å
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R-factor:
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0.170
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R-free:
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0.209
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Authors:
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J.K.F.Maclean,B.Kazemier
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Key ref:
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J.E.Harms
et al.
(2013).
Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.
Neuropharmacology,
64,
45-52.
PubMed id:
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Date:
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22-May-12
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Release date:
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11-Jul-12
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PROCHECK
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Headers
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References
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P19491
(GRIA2_RAT) -
Glutamate receptor 2 from Rattus norvegicus
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Seq:
Struc:
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883 a.a.
263 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 9 residue positions (black
crosses)
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Neuropharmacology
64:45-52
(2013)
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PubMed id:
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Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.
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J.E.Harms,
M.Benveniste,
J.K.Maclean,
K.M.Partin,
C.Jamieson.
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ABSTRACT
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Links
