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PDBsum entry 4f3g

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protein ligands metals links
Transport protein/agonist PDB id
4f3g

 

 

 

 

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Contents
Protein chain
258 a.a.
Ligands
KAI
Metals
_ZN
Waters ×306
PDB id:
4f3g
Name: Transport protein/agonist
Title: Kainate bound to the ligand binding domain of glua3i
Structure: Glutamate receptor 3. Chain: a. Synonym: glur-3, ampa-selective glutamate receptor 3, glur-c, glur- k3, glutamate receptor ionotropic, ampa 3, glua3. Engineered: yes
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: glur3, gria3, gria3. Glua3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.06Å     R-factor:   0.187     R-free:   0.245
Authors: A.H.Ahmed,R.E.Oswald
Key ref: S.M.Holley et al. (2012). The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry, 51, 4015-4027. PubMed id: 22512472
Date:
09-May-12     Release date:   30-May-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P19492  (GRIA3_RAT) -  Glutamate receptor 3 from Rattus norvegicus
Seq:
Struc:
 
Seq:
Struc:
888 a.a.
258 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 

 
Biochemistry 51:4015-4027 (2012)
PubMed id: 22512472  
 
 
The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.
S.M.Holley, A.H.Ahmed, J.Srinivasan, S.E.Murthy, G.A.Weiland, R.E.Oswald, L.M.Nowak.
 
  ABSTRACT  
 
No abstract given.

 

 

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