PDBsum entry 4exp

Cytokine/transferase

PDB id

4exp

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Contents

			Protein chains

					171 a.a.


					283 a.a.

			Ligands

					NAG ×4

			Waters ×198

PDB id:

4exp

Links

Name:

Cytokine/transferase

Title:

Structure of mouse interleukin-34 in complex with mouse fms

Structure:

Interleukin-34. Chain: a. Fragment: unp residues 21-194. Synonym: il-34. Engineered: yes. Macrophage colony-stimulating factor 1 receptor. Chain: x. Fragment: unp residues 20-298. Synonym: fms, csf-1 receptor, csf-1-r, csf-1r, m-csf-r, proto-

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: il34. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek. Gene: csf1r, csfmr, fms. Expression_system_cell_line: hek

Resolution:

2.80Å

R-factor:

0.249

R-free:

0.279

Authors:

H.Liu,C.Leo,X.Chen,B.R.Wong,L.T.Williams,H.Lin,X.He

Key ref:

H.Liu et al. (2012). The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim Biophys Acta, 1824, 938-945. PubMed id: 22579672

Date:

30-Apr-12

Release date:

30-May-12

PROCHECK

	Headers

	References

Protein chain

Q8R1R4 (IL34_MOUSE) - Interleukin-34 from Mus musculus

Seq: Struc:					235 a.a. 171 a.a.*

Protein chain

P09581 (CSF1R_MOUSE) - Macrophage colony-stimulating factor 1 receptor from Mus musculus

Seq: Struc:

Seq: Struc:					977 a.a. 283 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 7 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

Chain X: E.C.2.7.10.1 - receptor protein-tyrosine kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein]	+	ATP	=	O-phospho-L-tyrosyl-[protein] Bound ligand (Het Group name = NAG) matches with 41.38% similarity	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Biochim Biophys Acta 1824:938-945 (2012)
PubMed id: 22579672

The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
H.Liu, C.Leo, X.Chen, B.R.Wong, L.T.Williams, H.Lin, X.He.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23076159

K.Verstraete, and S.N.Savvides (2012).
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.

Nat Rev Cancer, 12, 753-766.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.