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PDBsum entry 4ewh
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Transferase/transferase inhibitor
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PDB id
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4ewh
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References listed in PDB file
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Key reference
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Title
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Synthesis and optimization of substituted furo[2,3-D]-Pyrimidin-4-Amines and 7h-Pyrrolo[2,3-D]pyrimidin-4-Amines as ack1 inhibitors.
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Authors
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X.Jiao,
D.J.Kopecky,
J.Liu,
J.Liu,
J.C.Jaen,
M.G.Cardozo,
R.Sharma,
N.Walker,
H.Wesche,
S.Li,
E.Farrelly,
S.H.Xiao,
Z.Wang,
F.Kayser.
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Ref.
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Bioorg Med Chem Lett, 2012,
22,
6212-6217.
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PubMed id
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Abstract
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Two classes of ACK1 inhibitors, 4,5,6-trisubstituted
furo[2,3-d]pyrimidin4-amines and 4,5,6-trisubstituted
7H-pyrrolo[2,3-d]pyrimidin-4-amines, were discovered and evaluated as ACK1
inhibitors. Further structural refinement led to the identification of potent
and selective dithiolane inhibitor 37.
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