UniProt functional annotation for Q5SID7



	UniProt functional annotation for Q5SID7

UniProt code: Q5SID7.

Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).

Taxonomy: Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.

Function: Activates transcription. Positively regulates six promoters upstream of the TTHB186, TTHB147, TTHB178, TTHB159, TTHA0771 and TTHA0176 genes in a cAMP-dependent manner. Regulated genes include clustered regularly interspaced short palindromic repeat (CRISPR) associated (Cas) genes, and the genes encoding a putative transcriptional regulator, a protein containing the exonuclease III- like domain of DNA polymerase, a GCN5-related acetyltransferase homolog, and some T.thermophilus-specific proteins of unknown function. The consensus DNA-binding site of this transcriptional regulator is 5'- (CT)NNG(G/T)(G/T)C(A/C)N(A/T)NNTCACAN(G/C)(G/C)-3' in which N is G, A, T or C. {ECO:0000269|PubMed:17369302}.

Subunit: Homodimer. {ECO:0000269|PubMed:17369302}.

Disruption phenotype: Decreased expression of genes downstream of the TTHB186, TTHB147 and TTHB159 genes. Decreased expression of TTHB178, TTHA0771 and TTHA0176 genes. {ECO:0000269|PubMed:17369302}.

Annotations taken from UniProtKB at the EBI.


Organism:		Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
Taxonomy:		Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.



Function:		Activates transcription. Positively regulates six promoters upstream of the TTHB186, TTHB147, TTHB178, TTHB159, TTHA0771 and TTHA0176 genes in a cAMP-dependent manner. Regulated genes include clustered regularly interspaced short palindromic repeat (CRISPR) associated (Cas) genes, and the genes encoding a putative transcriptional regulator, a protein containing the exonuclease III- like domain of DNA polymerase, a GCN5-related acetyltransferase homolog, and some T.thermophilus-specific proteins of unknown function. The consensus DNA-binding site of this transcriptional regulator is 5'- (CT)NNG(G/T)(G/T)C(A/C)N(A/T)NNTCACAN(G/C)(G/C)-3' in which N is G, A, T or C. {ECO:0000269\|PubMed:17369302}.


Subunit:		Homodimer. {ECO:0000269\|PubMed:17369302}.
Disruption phenotype:		Decreased expression of genes downstream of the TTHB186, TTHB147 and TTHB159 genes. Decreased expression of TTHB178, TTHA0771 and TTHA0176 genes. {ECO:0000269\|PubMed:17369302}.