 |
PDBsum entry 4eku
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Crystal structure of ferm domain of proline-rich tyrosine kinase 2
|
|
Structure:
|
|
Protein-tyrosine kinase 2-beta. Chain: a. Fragment: unp residues 21-409. Synonym: calcium-dependent tyrosine kinase, cadtk, calcium-regulated non-receptor proline-rich tyrosine kinase, cell adhesion kinase beta, cak-beta, cakb, focal adhesion kinase 2, fadk 2, proline-rich tyrosine kinase 2, related adhesion focal tyrosine kinase, raftk. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: fak2, nm4103, ptk2b, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
Resolution:
|
|
|
3.25Å
|
R-factor:
|
0.187
|
R-free:
|
0.212
|
|
|
Authors:
|
|
B.Savarimuthu,R.Li,Y.Wang
|
|
Key ref:
|
|
B.Savarimuthu
et al.
Crystal structure of the ferm domain of proline-Rich tyrosine kinase 2.
To be published,
.
|
|
|
Date:
|
|
|
09-Apr-12
|
Release date:
|
25-Apr-12
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q14289
(FAK2_HUMAN) -
Protein-tyrosine kinase 2-beta from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1009 a.a.
348 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
|
|
|
|
|
|
|
Reaction:
|
|
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
|
|
|
|
|
|
L-tyrosyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-tyrosyl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
