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PDBsum entry 4efb

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protein ligands links
Ligase/ligase inhibitor PDB id
4efb
Jmol
Contents
Protein chain
313 a.a.
Ligands
SO4 ×2
NMN
0OW
Waters ×284
PDB id:
4efb
Name: Ligase/ligase inhibitor
Title: Crystal structure of DNA ligase
Structure: DNA ligase. Chain: a. Synonym: polydeoxyribonucleotide synthase [nad(+)]. Engineered: yes
Source: Synthetic: yes. Enterococcus faecalis. Organism_taxid: 1351. Other_details: this sequence occurs naturally in bacterial
Resolution:
2.20Å     R-factor:   0.196     R-free:   0.277
Authors: Y.Wei,T.Wang,P.Charifson,W.Xu
Key ref: T.Wang et al. Crystal structure of DNA ligase. To be published, .
Date:
29-Mar-12     Release date:   03-Apr-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q837V6  (DNLJ_ENTFA) -  DNA ligase
Seq:
Struc:
 
Seq:
Struc:
676 a.a.
313 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.5.1.2  - Dna ligase (NAD(+)).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: NAD+ + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m)
NAD(+)
+ (deoxyribonucleotide)(n)
+ (deoxyribonucleotide)(m)
= AMP
+
beta-nicotinamide D-ribonucleotide
Bound ligand (Het Group name = NMN)
corresponds exactly
+ (deoxyribonucleotide)(n+m)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     DNA repair   2 terms 
  Biochemical function     DNA ligase (NAD+) activity     1 term