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PDBsum entry 4e75
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References listed in PDB file
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Key reference
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Title
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Structure determination of lpxd from the lipopolysaccharide-Synthesis pathway of acinetobacter baumannii.
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Authors
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J.Badger,
B.Chie-Leon,
C.Logan,
V.Sridhar,
B.Sankaran,
P.H.Zwart,
V.Nienaber.
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Ref.
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Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013,
69,
6-9.
[DOI no: ]
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PubMed id
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Abstract
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Acinetobacter baumannii is a Gram-negative bacterium that is resistant to many
currently available antibiotics. The protein LpxD is a component of the
biosynthetic pathway for lipopolysaccharides in the outer membrane of this
bacterium and is a potential target for new antibacterial agents. This paper
describes the structure determination of apo forms of LpxD in space groups P2(1)
and P4(3)22. These crystals contained six and three copies of the protein
molecule in the asymmetric unit and diffracted to 2.8 and 2.7 Å resolution,
respectively. A comparison of the multiple protein copies in the asymmetric
units of these crystals reveals a common protein conformation and a conformation
in which the relative orientation between the two major domains in the protein
is altered.
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