PDBsum entry 4e41

Immune system

PDB id: 4e41

Contents

Protein chains

179 a.a.

179 a.a.

15 a.a.

181 a.a.

236 a.a.

190 a.a.

Metals

_NA ×2

Waters ×172

PDB id:

4e41

Name:

Immune system

Title:

Structural basis for the recognition of mutant self by a tumor- specific, mhc class ii-restricted t cell receptor g4

Structure:

Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f. Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: hla-drb1. Gene: tpi1, tpi. Expression_system_taxid: 562

Resolution:

2.60Å R-factor: 0.201 R-free: 0.264

Authors:

L.Deng,R.J.Langley,Q.Wang,S.L.Topalian,R.A.Mariuzza

Key ref:

Lg et al. Stuturaral basis for the recognition of mutant self b t-S-Spepecific, Mhc class ii-Restricted t cell recept. Pnanatltl acad sci usa, .

Date:

11-Mar-12 Release date: 29-Aug-12

Protein chains

P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain from Homo sapiens

Seq: 254 a.a.

Struc: 179 a.a.

Protein chains

P01911  (2B1F_HUMAN) -  HLA class II histocompatibility antigen, DRB1 beta chain from Homo sapiens

Seq: 266 a.a.

Struc: 179 a.a.*

Protein chains

P60174  (TPIS_HUMAN) -  Triosephosphate isomerase from Homo sapiens

Seq: 249 a.a.

Struc: 15 a.a.*

Protein chain

No UniProt id for this chain

Struc: 181 a.a.

Protein chains

No UniProt id for this chain

Struc: 236 a.a.

Protein chain

No UniProt id for this chain

Struc: 190 a.a.

* PDB and UniProt seqs differ at 14 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: Chains C, H: E.C.4.2.3.3 - methylglyoxal synthase.
• Reaction: dihydroxyacetone phosphate = methylglyoxal + phosphate
• Enzyme class 3: Chains C, H: E.C.5.3.1.1 - triose-phosphate isomerase.
• Reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site