PDBsum entry 4e3b

Signaling protein/protein binding

PDB id: 4e3b

Contents

Protein chains

102 a.a.

Ligands

SER-ARG-TRP-PRO-THR-SER-ILE-LEU

ASN-SER-ARG-TRP-PRO-THR-SER-ILE-LEU

Waters ×270

PDB id:

4e3b

Name:

Signaling protein/protein binding

Title:

Crystal structure of tax-interacting protein-1 (tip-1) pdz domain bound to ical36-l (ansrwptsil) peptide

Structure:

Tax1-binding protein 3. Chain: a, b. Fragment: pdz domain (unp residues 11-112). Synonym: tip-1, glutaminase-interacting protein 3, tax interaction protein 1. Engineered: yes. Ical50 peptide. Chain: c, d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tax1bp3, tip1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes

Resolution:

1.50Å R-factor: 0.189 R-free: 0.216

Authors:

J.F.Amacher,D.R.Madden

Key ref:

J.F.Amacher et al. (2013). Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop. J Biol Chem, 288, 5114-5126. PubMed id: 23243314 DOI: 10.1074/jbc.M112.401588

Date:

09-Mar-12 Release date: 26-Dec-12

Protein chains

O14907  (TX1B3_HUMAN) -  Tax1-binding protein 3 from Homo sapiens

Seq: 124 a.a.

Struc: 102 a.a.

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1074/jbc.M112.401588

J Biol Chem 288:5114-5126 (2013)

PubMed id: 23243314

Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.

J.F.Amacher, P.R.Cushing, C.D.Bahl, T.Beck, D.R.Madden.

ABSTRACT

No abstract given.