PDBsum entry 4dx5

Membrane protein, transport protein

PDB id: 4dx5

Contents

Protein chains

1044 a.a.

156 a.a.

Ligands

GOL ×15

LMT ×8

OCT ×7

D10 ×6

HEX ×5

D12 ×4

MIY

C14

LMU

DD9

SO4

UND

Waters ×1783

PDB id:

4dx5

Name:

Membrane protein, transport protein

Title:

Transport of drugs by the multidrug transporter acrb involves an access and a deep binding pocket that are separated by a switch-loop

Structure:

Acriflavine resistance protein b. Chain: a, b, c. Engineered: yes. Darpin. Chain: d, e. Engineered: yes

Source:

Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: acrb, acre, b0462, jw0451. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Artificial gene. Organism_taxid: 32630.

Resolution:

1.90Å R-factor: 0.202 R-free: 0.231

Authors:

T.Eicher,H.Cha,M.A.Seeger,L.Brandstaetter,J.El-Delik,J.A.Bohnert, W.V.Kern,F.Verrey,M.G.Gruetter,K.Diederichs,K.M.Pos

Key ref:

T.Eicher et al. (2012). Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A, 109, 5687-5692. PubMed id: 22451937

Date:

27-Feb-12 Release date: 02-May-12

Protein chains

P31224  (ACRB_ECOLI) -  Multidrug efflux pump subunit AcrB from Escherichia coli (strain K12)

Seq: 1049 a.a.

Struc: 1044 a.a.

Protein chains

No UniProt id for this chain

Struc: 156 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C: E.C.?

Proc Natl Acad Sci U S A 109:5687-5692 (2012)

PubMed id: 22451937

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.

T.Eicher, H.J.Cha, M.A.Seeger, L.Brandstätter, J.El-Delik, J.A.Bohnert, W.V.Kern, F.Verrey, M.G.Grütter, K.Diederichs, K.M.Pos.

ABSTRACT

No abstract given.