PDBsum entry 4dx2

Transport protein

PDB id: 4dx2

Contents

Protein chain

247 a.a.

Ligands

BGC

ATP

GOL

Waters ×72

PDB id:

4dx2

Name:

Transport protein

Title:

Crystal structure of the human trpv4 ankyrin repeat domain

Structure:

Transient receptor potential cation channel subfamily v member 4. Chain: a, b. Fragment: n-terminal domain (unp residues 149-397). Synonym: trpv4, osm-9-like trp channel 4, otrpc4, transient receptor potential protein 12, trp12, vanilloid receptor-like channel 2, vanilloid receptor-like protein 2, vrl-2, vanilloid receptor-related osmotically-activated channel, vr-oac. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: trpv4, vrl2, vroac. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.95Å R-factor: 0.179 R-free: 0.220

Authors:

H.Inada,R.Gaudet

Key ref:

H.Inada et al. (2012). Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51, 6195-6206. PubMed id: 22702953

Date:

27-Feb-12 Release date: 18-Jul-12

Protein chains

Q9HBA0  (TRPV4_HUMAN) -  Transient receptor potential cation channel subfamily V member 4 from Homo sapiens

Seq: 871 a.a.

Struc: 247 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?

Biochemistry 51:6195-6206 (2012)

PubMed id: 22702953

Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.

H.Inada, E.Procko, M.Sotomayor, R.Gaudet.

ABSTRACT

No abstract given.