PDBsum entry 4dtg

Blood clotting inhibitor/immune system

PDB id: 4dtg

Contents

Protein chains

219 a.a.

221 a.a.

60 a.a.

Ligands

GOL ×10

MES

PGE ×3

Waters ×400

PDB id:

4dtg

Name:

Blood clotting inhibitor/immune system

Title:

Hemostatic effect of a monoclonal antibody mab 2021 blocking the interaction between fxa and tfpi in a rabbit hemophilia model

Structure:

Humanized recombinant fab fragment, fab 2021, of a murine antibody, light chain. Chain: l. Engineered: yes. Humanized recombinant fab fragment, fab 2021, of a murine antibody, heavy chain. Chain: h. Engineered: yes. Tissue factor pathway inhibitor.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney 293 cells. Gene: laci, tfpi, tfpi (amino acids 119-178), tfpi1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.80Å R-factor: 0.198 R-free: 0.236

Authors:

L.A.Svensson,J.Breinholt,B.O.Krogh,I.Hilden

Key ref:

I.Hilden et al. (2012). Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model. Blood, 119, 5871-5878. PubMed id: 22563084

Date:

21-Feb-12 Release date: 13-Jun-12

Protein chain

No UniProt id for this chain

Struc: 219 a.a.

Protein chain

No UniProt id for this chain

Struc: 221 a.a.

Protein chain

P10646  (TFPI1_HUMAN) -  Tissue factor pathway inhibitor from Homo sapiens

Seq: 304 a.a.

Struc: 60 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Blood 119:5871-5878 (2012)

PubMed id: 22563084

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.

I.Hilden, B.Lauritzen, B.B.Sørensen, J.T.Clausen, C.Jespersgaard, B.O.Krogh, A.N.Bowler, J.Breinholt, A.Gruhler, L.A.Svensson, H.H.Petersen, L.C.Petersen, K.W.Balling, L.Hansen, M.B.Hermit, T.Egebjerg, B.Friederichsen, M.Ezban, S.E.Bjørn.

ABSTRACT

No abstract given.