PDBsum entry 4doh

Signaling protein

PDB id: 4doh

Contents

Protein chains

153 a.a.

193 a.a.

204 a.a.

Ligands

NAG ×5

Waters ×57

PDB id:

4doh

Name:

Signaling protein

Title:

Il20/il201/il20r2 ternary complex

Structure:

Interleukin-20. Chain: a, c. Synonym: il-20, cytokine zcyto10. Engineered: yes. Mutation: yes. Interleukin-20 receptor subunit beta. Chain: b, d. Synonym: il-20 receptor subunit beta, il-20r-beta, il-20rb, il-20r2. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: il20, zcyto10, unq852/pro1801. Expressed in: drosophila. Expression_system_taxid: 7215. Gene: il20rb, dirs1, unq557/pro1114. Gene: il20ra, unq681/pro1315. Expression_system_taxid: 7215

Resolution:

2.80Å R-factor: 0.230 R-free: 0.278

Authors:

N.J.Logsdon,M.R.Walter

Key ref:

N.J.Logsdon et al. (2012). Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci U S A, 109, 12704-12709. PubMed id: 22802649

Date:

09-Feb-12 Release date: 18-Jul-12

Protein chains

Q9NYY1  (IL20_HUMAN) -  Interleukin-20 from Homo sapiens

Seq: 176 a.a.

Struc: 153 a.a.*

Protein chains

Q6UXL0  (I20RB_HUMAN) -  Interleukin-20 receptor subunit beta from Homo sapiens

Seq: 311 a.a.

Struc: 193 a.a.*

Protein chains

Q9UHF4  (I20RA_HUMAN) -  Interleukin-20 receptor subunit alpha from Homo sapiens

Seq: 553 a.a.

Struc: 204 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Proc Natl Acad Sci U S A 109:12704-12709 (2012)

PubMed id: 22802649

Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.

N.J.Logsdon, A.Deshpande, B.D.Harris, K.R.Rajashankar, M.R.Walter.

ABSTRACT

No abstract given.