PDBsum entry 4dmb

Immune system

PDB id: 4dmb

Contents

Protein chain

188 a.a.

Ligands

NO3 ×3

GOL

PO4 ×2

PEG ×2

UNL

Metals

_MG ×4

Waters ×172

PDB id:

4dmb

Name:

Immune system

Title:

X-ray structure of human hepatitus c virus ns5a-transactivated protein 2 at the resolution 1.9a, northeast structural genomics consortium (nesg) target hr6723

Structure:

Hd domain-containing protein 2. Chain: a, b. Synonym: hepatitis c virus ns5a-transactivated protein 2, hcv ns5a- transactivated protein 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3)+ magic. Gene: hddc2, c6orf74, ns5atp2, cgi-130. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.90Å R-factor: 0.177 R-free: 0.207

Authors:

A.Kuzin,M.Su,J.Seetharaman,P.Patel,R.Xiao,C.Ciccosanti,D.Lee, J.K.Everett,T.B.Acton,G.T.Montelione,J.F.Hunt,L.Tong,Northeast Structural Genomics Consortium (Nesg),Mitochondrial Protein Partnership (Mpp)

Key ref:

A.Kuzin et al. Northeast structural genomics consortium target hr672. To be published, .

Date:

07-Feb-12 Release date: 04-Apr-12

Protein chains

Q7Z4H3  (HDDC2_HUMAN) -  5'-deoxynucleotidase HDDC2 from Homo sapiens

Seq: 204 a.a.

Struc: 188 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.3.89 - 5'-deoxynucleotidase.
• Reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate

2'-deoxyribonucleoside 5'-phosphate + H2O = 2'-deoxyribonucleoside + phosphate (Bound ligand (Het Group name = PO4) corresponds exactly)

• Cofactor: Cobalt cation

Molecule diagrams generated from .mol files obtained from the KEGG ftp site