PDBsum entry 4dm6

Transcription/protein binding

PDB id: 4dm6

Contents

Protein chains

240 a.a.

11 a.a.

12 a.a.

Ligands

TTB ×2

Waters ×178

PDB id:

4dm6

Name:

Transcription/protein binding

Title:

Crystal structure of rarb lbd homodimer in complex with ttnpb

Structure:

Retinoic acid receptor beta. Chain: a, b. Fragment: unp residues 176-421. Synonym: rar-beta, hbv-activated protein, nuclear receptor subfamily 1 group b member 2, rar-epsilon. Engineered: yes. Nuclear receptor coactivator 1. Chain: e, f. Fragment: unp residues 676-700.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rarb, hap, nr1b2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.90Å R-factor: 0.206 R-free: 0.239

Authors:

J.Osz,Y.Brelivet,C.Peluso-Iltis,V.Cura,S.Eiler,M.Ruff,W.Bourguet, N.Rochel,D.Moras

Key ref:

J.Osz et al. (2012). Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors. Proc Natl Acad Sci U S A, 109, E588. PubMed id: 22355136

Date:

07-Feb-12 Release date: 07-Mar-12

Protein chains

P10826  (RARB_HUMAN) -  Retinoic acid receptor beta from Homo sapiens

Seq: 455 a.a.

Struc: 240 a.a.

Protein chain

Q15788  (NCOA1_HUMAN) -  Nuclear receptor coactivator 1 from Homo sapiens

Seq: 1441 a.a.

Struc: 11 a.a.

Protein chain

Q15788  (NCOA1_HUMAN) -  Nuclear receptor coactivator 1 from Homo sapiens

Seq: 1441 a.a.

Struc: 12 a.a.

Enzyme reactions

• Enzyme class: Chains E, F: E.C.2.3.1.48 - histone acetyltransferase.
• Reaction: L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Proc Natl Acad Sci U S A 109:E588 (2012)

PubMed id: 22355136

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.

J.Osz, Y.Brélivet, C.Peluso-Iltis, V.Cura, S.Eiler, M.Ruff, W.Bourguet, N.Rochel, D.Moras.

ABSTRACT

No abstract given.