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PDBsum entry 4dkd
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Cytokine/transferase
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PDB id
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4dkd
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PDB id:
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Cytokine/transferase
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Title:
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Crystal structure of human interleukin-34 bound to human csf-1r
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Structure:
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Interleukin-34. Chain: a, b. Fragment: active core, unp residues 21-193. Synonym: il-34. Engineered: yes. Macrophage colony-stimulating factor 1 receptor. Chain: c. Fragment: d1-d3, unp residues 20-299. Synonym: csf-1 receptor, csf-1-r, csf-1r, m-csf-r, proto-oncogenE C-
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: il34, c16orf77. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tni pro. Gene: csf1r, fms. Expression_system_cell_line: tni pro
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Resolution:
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3.00Å
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R-factor:
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0.254
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R-free:
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0.287
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Authors:
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X.Ma,J.F.Bazan,M.A.Starovasnik
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Key ref:
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X.Ma
et al.
(2012).
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
Structure,
20,
676-687.
PubMed id:
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Date:
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03-Feb-12
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Release date:
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11-Apr-12
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PROCHECK
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Headers
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References
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Enzyme class:
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Chain C:
E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
Bound ligand (Het Group name = )
matches with 41.38% similarity
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Structure
20:676-687
(2012)
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PubMed id:
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Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
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X.Ma,
W.Y.Lin,
Y.Chen,
S.Stawicki,
K.Mukhyala,
Y.Wu,
F.Martin,
J.F.Bazan,
M.A.Starovasnik.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.Elegheert,
N.Bracke,
P.Pouliot,
I.Gutsche,
A.V.Shkumatov,
N.Tarbouriech,
K.Verstraete,
A.Bekaert,
W.P.Burmeister,
D.I.Svergun,
B.N.Lambrecht,
B.Vergauwen,
and
S.N.Savvides
(2012).
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
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Nat Struct Mol Biol,
19,
938-947.
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PDB codes:
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K.Verstraete,
and
S.N.Savvides
(2012).
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.
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Nat Rev Cancer,
12,
753-766.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
