PDBsum entry 4djc

Calcium-binding protein

PDB id: 4djc

Contents

Protein chains

151 a.a.

13 a.a.

Ligands

IPA ×9

Metals

_CA ×4

Waters ×161

PDB id:

4djc

Name:

Calcium-binding protein

Title:

1.35 a crystal structure of the nav1.5 diii-iv-ca/cam complex

Structure:

Calmodulin. Chain: a. Synonym: cam. Engineered: yes. Sodium channel protein type 5 subunit alpha. Chain: b. Synonym: hh1, sodium channel protein cardiac muscle subunit alpha, sodium channel protein type v subunit alpha, voltage-gated sodium channel subunit alpha nav1.5.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: calm1, calm, cam, cam1, calm2, cam2, camb, calm3, calml2, cam3, camc, camiii. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: scn5a. Expression_system_taxid: 562

Resolution:

1.35Å R-factor: 0.154 R-free: 0.176

Authors:

M.F.Sarhan,C.-C.Tung,F.Van Petegem,C.A.Ahern

Key ref:

M.F.Sarhan et al. (2012). Crystallographic basis for calcium regulation of sodium channels. Proc Natl Acad Sci U S A, 109, 3558-3563. PubMed id: 22331908

Date:

01-Feb-12 Release date: 22-Feb-12

Protein chain

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 151 a.a.

Protein chain

Q14524  (SCN5A_HUMAN) -  Sodium channel protein type 5 subunit alpha from Homo sapiens

Seq: 2016 a.a.

Struc: 13 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Proc Natl Acad Sci U S A 109:3558-3563 (2012)

PubMed id: 22331908

Crystallographic basis for calcium regulation of sodium channels.

M.F.Sarhan, C.C.Tung, F.Van Petegem, C.A.Ahern.

ABSTRACT

No abstract given.