|
|
||
|
|
|
|
|
UniProt functional annotation for P31321 | ||
|
|
|
|
|
|
||
| UniProt code: P31321. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
|
||
| Subunit: | |
The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma membrane. {ECO:0000269|PubMed:20819953, ECO:0000269|PubMed:23115245}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:23115245}. |
| Tissue specificity: | |
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Ptm: | |
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. |
| Similarity: | |
Belongs to the cAMP-dependent kinase regulatory chain family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.