PDBsum entry 4dex

Transport protein

PDB id: 4dex

Contents

Protein chains

289 a.a.

45 a.a.

Waters ×162

PDB id:

4dex

Name:

Transport protein

Title:

Crystal structure of the voltage dependent calcium channel beta-2 subunit in complex with the cav2.2 i-ii linker.

Structure:

Voltage-dependent l-type calcium channel subunit beta-2. Chain: a. Synonym: cab2, calcium channel voltage-dependent subunit beta 2. Engineered: yes. Voltage-dependent n-type calcium channel subunit alpha-1b. Chain: b. Fragment: intracellular i-ii linker. Synonym: brain calcium channel iii, biii, calcium channel, l type, alpha-1 polypeptide isoform 5, voltage-gated calcium channel subunit

Source:

Oryctolagus cuniculus. European rabbit,japanese white rabbit,domestic rabbit,rabbits. Organism_taxid: 9986. Gene: cacnb2, cacnlb2. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Brown rat,rat,rats.

Resolution:

2.00Å R-factor: 0.200 R-free: 0.238

Authors:

L.Almagor,J.A.Hirsch

Key ref:

L.Almagor et al. (2012). The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis. J Neurosci, 32, 7602-7613. PubMed id: 22649239

Date:

22-Jan-12 Release date: 13-Jun-12

Protein chain

P54288  (CACB2_RABIT) -  Voltage-dependent L-type calcium channel subunit beta-2 from Oryctolagus cuniculus

Seq: 632 a.a.

Struc: 289 a.a.*

Protein chain

Q02294  (CAC1B_RAT) -  Voltage-dependent N-type calcium channel subunit alpha-1B from Rattus norvegicus

Seq: 2336 a.a.

Struc: 45 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?

J Neurosci 32:7602-7613 (2012)

PubMed id: 22649239

The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.

L.Almagor, O.Chomsky-Hecht, A.Ben-Mocha, D.Hendin-Barak, N.Dascal, J.A.Hirsch.

ABSTRACT

No abstract given.