UniProt functional annotation for Q92913



	UniProt functional annotation for Q92913

UniProt code: Q92913.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (PubMed:15282281). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). {ECO:0000250|UniProtKB:P70377, ECO:0000269|PubMed:15282281}.

Subunit: Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity. {ECO:0000269|PubMed:11378392, ECO:0000269|PubMed:15282281, ECO:0000269|PubMed:19406745, ECO:0000269|PubMed:21566136, ECO:0000269|PubMed:21817159}.

Subcellular location: Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10644718}. Cytoplasm {ECO:0000269|PubMed:10644718}. Note=Not secreted. {ECO:0000250}.

Subcellular location: [Isoform 1]: Nucleus, nucleolus.

Subcellular location: [Isoform 2]: Cytoplasm. Nucleus.

Tissue specificity: Ubiquitously expressed. Predominantly expressed in the nervous system. {ECO:0000269|PubMed:9232594}.

Ptm: May be phosphorylated. {ECO:0000250}.

Similarity: Belongs to the heparin-binding growth factors family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (PubMed:15282281). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). {ECO:0000250\|UniProtKB:P70377, ECO:0000269\|PubMed:15282281}.


Subunit:		Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity. {ECO:0000269\|PubMed:11378392, ECO:0000269\|PubMed:15282281, ECO:0000269\|PubMed:19406745, ECO:0000269\|PubMed:21566136, ECO:0000269\|PubMed:21817159}.
Subcellular location:		Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Nucleus {ECO:0000269\|PubMed:10644718}. Cytoplasm {ECO:0000269\|PubMed:10644718}. Note=Not secreted. {ECO:0000250}.
Subcellular location:		[Isoform 1]: Nucleus, nucleolus.
Subcellular location:		[Isoform 2]: Cytoplasm. Nucleus.
Tissue specificity:		Ubiquitously expressed. Predominantly expressed in the nervous system. {ECO:0000269\|PubMed:9232594}.
Ptm:		May be phosphorylated. {ECO:0000250}.
Similarity:		Belongs to the heparin-binding growth factors family. {ECO:0000305}.